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Clinical trials that are designed to help inform practice in the real world are called pragmatic trials. They are often described as focusing on practical aspects of design which include recruitment and consent, adherence and the use of routinely available equipment.

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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which used various investigators and 프라그마틱 이미지 included participants from different geographical regions. This kind of heterogeneity is necessary for practical trials to be valid, and it also helps to reduce the chance of bias in the results. However too much heterogeneity could lead to problems with the design of the trial.

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Pragmatic trials aim to mimic real-life settings and achieve maximum external validity. They are usually ordered by policymakers and practitioners to guide their decisions. They are also a good way to identify the cause-effect relationship between an intervention and its results. However, they should not be used as a substitute for the use of explanation trials.

The pragmatism idea is controversial, and there are questions regarding whether pragmatic trials could be used to replace explanation tests or if they should be an alternative to them. Schwartz and Lellouch1 proposed a distinction between explanatory studies, which confirm the physiological hypothesis or clinical hypothesis, and pragmatic trials that aid in policy and practice decision-making. They also proposed a framework called PRECIS for pragmatic trials.2 This tool tried to define the characteristics of a pragmatic study that includes recruitment, design, delivery of the intervention, and follow-up.

The number of pragmatic trials is increasing. A recent Medline search using the keywords pragmatic and naturalistic, restricted to controlled trials randomized to control (RCTs) resulted in 34 articles, which are shown in red in Figure 2. This suggests that the health sciences community is becoming more aware of the importance of pragmatism. It is important to remember, however, that the majority of studies were conducted in primary-care settings.